Essential Function of Oncostatin M in Nociceptive Neurons of Dorsal Root Ganglia
نویسندگان
چکیده
منابع مشابه
Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia.
Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines, and we have reported previously that the murine OSM receptor beta subunit (OSMR) was expressed in some neurons in the adult trigeminal and dorsal root ganglia (DRGs) and in the perineonatal hypoglossal nucleus. In the present study, we investigated the development of OSMR-positive neurons of DRGs in OSM-deficient mice. In ...
متن کاملConditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia.
The use of Cre-loxP technology for conditional mutagenesis in pain pathways had been restricted by the unavailability of mice expressing Cre recombinase selectively in functionally distinct components of the nociceptive system. Here we describe the generation of transgenic mouse lines which express Cre recombinase selectively in sensory ganglia using promoter elements of the Na(v)1.8 gene (Scn1...
متن کاملRole of myosin Va in neuritogenesis of chick dorsal root ganglia nociceptive neurons.
Myosin-Va, widely distributed throughout the developing nervous system, is involved in the transport of vesicles and other intracellular components with its globular tail domain (GTD) implicated in cargo recognition/interaction. Inactivation of myosin-Va in dorsal root ganglia (DRG) neurons of chick embryos, in vitro, decreases the rate of filopodial extension. MYO5A mutant mice have severe neu...
متن کاملMCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia.
Previous experimental results from our laboratory demonstrated that monocyte chemoattractant protein-1 (MCP-1) depolarizes or increases the excitability of nociceptive neurons in the intact dorsal root ganglion (DRG) after a chronic compression of the DRG (CCD), an injury that upregulates neuronal expression of both MCP-1 and mRNA for its receptor CCR2. We presently explore the ionic mechanisms...
متن کاملPaclitaxel-Resistant Neurons in Dorsal Root Ganglia
Paclitaxel is an antineoplastic drug, and its usage is often limited by severe peripheral polyneuropathy characterized by symptoms in remote extremities. It is suggested that subpopulations of dorsal root ganglion (DRG) neurons are impacted functionally and/or structurally. In this study, the neurotoxic effect of this drug in cultured rat DRG neurons was analyzed by measuring their neurite leng...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2004
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4975-03.2004